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Protein Kinase Inhibitor: Indirubin

No.175(October 2017)
Indirubin  (1)
Indirubin (1) is an inhibitor of protein kinases (Table).1,2) According to a crystal structure study of CDK2 in complexation with indirubin derivatives has shown that 1 interacts with the ATP-binding site of the kinase.1) 1 also was reported to have high binding affinity with the aryl hydrocarbon receptor (AhR).3)
In DNCB-induced mice, 1 inhibited allergic contact dermatitis by regulating T helper mediated immune system.4)
CDK: cyclin-dependent kinase
DNCB: 1-chloro-2,4-dinitrobenzene

Table. Inhibition of kinases by indirubin
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