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4-[2,2,2-Trifluoro-1-[(trimethylsilyl)oxy]ethyl]morpholine
(CAS Number:289706-46-3 Product Number:T3597)

Structure

4-[2,2,2-Trifluoro-1-[(trimethylsilyl)oxy]ethyl]morpholine

General Information

Product Number T3597

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Purity/Analysis Method >95.0%(GC)
Storage Temperature
M.F. / M.W. C9H18F3NO2Si=257.33
CAS Number 289706-46-3
Related CAS Number
MDL Number
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(GC) min. 95.0 %
Refractive index n20/D 1.4060 to 1.4100

References

Reaxys-RN 8622317

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H227
  • :Combustible liquid.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P210
  • :Keep away from flames and hot surfaces. – No smoking.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P403+P235
  • :Store in a well-ventilated place. Keep cool.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Application

Morpholine Derivative Usable for Introduction of a Trifluoromethyl Group

T3597

Trifluoromethylation of Aryl Iodides2): A Schlenk tube is charged with CuI (0.030 mmol, 5.7 mg), 1,10-phenanthroline (0.030 mmol, 5.4 mg) and CsF (0.60 mmol, 67.3 mg). The tube is evacuated and backfilled with argon, and then diglyme (0.60 mL), 4-nitroiodobenzene (0.30 mmol, 74.7 mg), and 1 (0.60 mmol, 154 mg) are added. The resulting reaction mixture is stirred at 80 °C for 24 h. After the reaction is complete, the mixture is cooled to room temperature, diluted with water, and extracted with ethyl acetate. The combined organic layers are washed with brine, dried over MgSO4, filtered, and the volatiles are removed in vacuo. The residue is purified by chromatography on silica gel to yield 4-nitrobenzotrifluoride (77% yield).

References

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