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CAS RN: 76095-16-4 | Product Number: E1010
Enalapril Maleate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-L-proline Maleate
Product Documents:
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| Product Number | E1010 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__8N__2O__5·C__4H__4O__4 = 492.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 76095-16-4 |
| Related CAS RN
|
75847-73-3 |
| Reaxys Registry Number | 3645274 |
| PubChem Substance ID | 253661645 |
| Merck Index (14) | 3567 |
| MDL Number | MFCD00133304 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -40.0 to -43.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 144 °C(dec.) |
| Specific Rotation | -41° (C=1,MeOH) |
| Maximum Absorption Wavelength | 208 nm (MeOH) |
| Solubility in water | Slightly soluble |
| Degree of solubility in water | 25 g/l 25 °C |
| Solubility (soluble in) | Ethanol |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| RTECS# | TW3666000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Enalapril Maleate: An Angiotensin-Converting Enzyme Inhibitor (ACEI)
Enalapril maleate is an angiotensin-converting enzyme inhibitor (ACEI) without a mercapto group, used in the treatment of hypertension. Enalapril is a prodrug which is hydrolysed by various esterases in the host's liver to form the ACEI, enalaprilat [E1302]. Enalapril increases plasma renin activity (PRA) and decreases plasma concentrations of angiotensin II and aldosterone. (The product is for research purpose only.)
References
- Enalapril maleate (MK-421), a potent, nonsulfhydryl angiotensin-converting enzyme inhibitor: absorption, disposition, and metabolism in man (a review)
- Enalapril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure (a review)
- Enalapril maleate (a review)
- Enalapril: pharmacokinetic/dynamic inferences for comparative developmental toxicity (a review)
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