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(CAS Number:170729-80-3 Product Number:A3135)


Synonym 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

General Information

Product Number A3135

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C23H21F7N4O3=534.43
CAS Number 170729-80-3
Related CAS Number
MDL Number MFCD08277635
Packaging and Container 500mg-Plastic Bottle with Glass Insert, (View image) 100mg-Plastic Bottle with Glass Insert (View image)
  • Product Details
  • Safety & Regulations


Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 97.0 %
Melting point 250.0 to 255.0 deg-C
Specific rotation [a]20/D +67.0 to +71.0 deg(C=1,MeOH)


Reaxys-RN 8096869
Merck Index(14) 753
RTECS# XZ5480400


Signal Word Warning
Hazard Statements
  • H319
  • :Causes serious eye irritation.
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.

Transport Information

HS Number 2934999090


Aprepitant: A Selective High-Affinity Antagonist of the Substance P/Neurokinin 1 (NK1) Receptors

Aprepitant is a selective high-affinity antagonist of the substance P/neurokinin 1 (NK1) receptors. Aprepitan crosses the blood barrier, and then aprepitan occupies brain NK1 receptors and blocks the binding of substance P to the receptors. (Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.) Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Aprepitant is used for the treatment of nausea and vomiting. (The product is for research purpose only.)


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