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Landiolol Hydrochloride
(CAS Number:144481-98-1 Product Number:L0296)

Structure

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Landiolol Hydrochloride

General Information

Product Number L0296

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C25H39N3O8·HCl=546.06
CAS Number 144481-98-1
Related CAS Number 133242-30-5
MDL Number MFCD00911043
Packaging and Container 50mg-Plastic Bottle with Glass Insert, (View image) 250mg-Plastic Bottle with Glass Insert (View image)
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 124.0 to 128.0 deg-C

References

Reaxys-RN 5845039
RTECS# DA8346700

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2934999090

Application

Landiolol Hydrochloride: A Highly Cardioselective, Short-Acting Adrenergic β1-Selective Antagonist

Landiolol hydrochloride (ONO-1101) is a highly cardioselective, short-acting adrenergic β1-selective antagonist (blocker). Landiolol reduces heart rate by selectively blocking β1 receptors located chiefly in the heart. It is reported that landiolol has 8-fold greater cardioselectivity than esmolol [E1106] in vitro. Landiolol is a short-acting agent since the ester group of landiolol is rapidly hydrolyzed to an inactivate metabolite by esterases in plasma and liver. Landiolol hydrochloride is used for the treatment of tachyarrhythmia and better control of heart rate in surgery. (The product is for research purpose only.)

References

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