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Procarbazine Hydrochloride
(CAS Number:366-70-1 Product Number:P2550)

Structure

Procarbazine Hydrochloride
Synonym N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride

General Information

Product Number P2550

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C12H19N3O·HCl=257.76
CAS Number 366-70-1
Related CAS Number 671-16-9
MDL Number MFCD00072082
Packaging and Container 500mg-Plastic Bottle with Glass Insert, (View image) 100mg-Plastic Bottle with Glass Insert (View image)
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Argentmetric Titration) min. 98.0 %

Data of Reference

mp 226°C(lit.)

References

Reaxys-RN 4024454
Merck Index(14) 7758
RTECS# XS4725000
EC Number 206-678-6

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H341
  • :Suspected of causing genetic defects.
  • H350
  • :May cause cancer.
  • H360FD
  • :May damage fertility. May damage the unborn child.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :IF exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.

Transport Information

HS Number 2928009090

Application

Procarbazine: An Antitumor Alkylating Agent

Procarbazine is an antitumor alkylating agent that was first synthesized in the late 1950s. Reportedly, procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA, and the non-functioning t-RNA could cause the cessation of DNA, RNA, and protein synthesis.
In addition, procarbazine can also directly damage DNA through an alkylation reaction. Alkylating agents including procarbazine are known to be associated with production of reactive oxygen species (ROS) which may attack protein sulfhydryl groups contained in protein which is tightly bound to DNA. Procarbazine is not cross-resistant with other alkylating agents. Procarbazine has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's disease and brain tumors, since it can cross the blood-brain barrier. (The product is for research purpose only.)

References

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