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Nα-(5-Fluoro-2,4-dinitrophenyl)-L-leucinamide [HPLC Labeling Reagent for e.e. Determination]
(CAS Number:178065-29-7 Product Number:A5523)

Structure

Nalpha-(5-Fluoro-2,4-dinitrophenyl)-L-leucinamide

General Information

Product Number A5523

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C12H15FN4O5=314.27
CAS Number 178065-29-7
Related CAS Number
MDL Number MFCD03844761
Packaging and Container 100mg-Plastic Bottle with Glass Insert (View image)
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Optical purity(LC) min. 99.0 ee%
Melting point 168.0 to 172.0 deg-C
Specific rotation [a]20/D +3.0 to +7.0 deg(C=1, Acetone)
Effect test of HPLC derivatization to pass test

Data of Reference

ee >99.0%(HPLC)

References

Reaxys-RN 8157683
PubChem SID 87563164

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H228
  • :Flammable solid.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P210
  • :Keep away from heat/sparks/open flames/hot surfaces. ― No smoking.
  • P241
  • :Use explosion-proof electrical/ventilating/lighting equipment.
  • P264
  • :Wash hands thoroughly after handling.
  • P280
  • :Wear protective gloves/eye protection/face protection.
  • P302+P350
  • :IF ON SKIN: Gently wash with plenty of soap and water.
  • P305+P351+P338
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P332+P313
  • :If skin irritation occurs: Get medical advice/attention.
  • P337+P313
  • :If eye irritation persists: Get medical advice/attention.
  • P362
  • :Take off contaminated clothing and wash before reuse.

Risk Phrases

Risk Phrases
  • R36/37/38
  • :Irritating to eyes, respiratory system and skin.

Safety Phrases

Safety Phrases
  • S26
  • :In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • S36
  • :Wear suitable protective clothing.

Transport Information

UN Number 1325
Class 4.1
Packing Group III
HS Number 2924299899

Application

HPLC Labeling Reagent for Amines

The compound 1 and 2 are HPLC labeling reagents for optical purity determination, and can easily react with amino groups. 1 or 2 reacts with a racemic amino acid to generate diastereomers, which can be efficiently separated by reversed phase HPLC. The absolute configuration of amino acids also can be non-empirically determined with use of 1 and 2. Furthermore, high sensitive analyses can easily be accomplished using LC-MS. [The detection limit: 5 pmol (ESI LC-MS)]

Application examples:
[Amino acids] 2)
To 50 μL of a 50 mM aqueous solution of amino acids are added 20 μL of 1 M NaHCO3 and then 100 μL of 1% labeling reagent 1 or 2 in acetone. The solution is incubated at 37 ºC for 1 h. Reactions are quenched by addition of 20 μL of 1 N HCl. Samples are diluted with 810 μL of acetonitrile, and 1 μL of this solution is analyzed by LC-MS.

References

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