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Zopiclone
（CAS Number：43200-80-2）

Structure

Synonym	6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-Methyl-1-piperazinecarboxylate

General Information

Product Number	Z0018

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Storage Temperature
Purity/Analysis Method	>98.0%(LC)(T)
M.F. / M.W.	C₁₇H₁₇ClN₆O₃=388.81
CAS Number	43200-80-2
Related CAS Number
MDL Number	MFCD00133931
Packaging and Container	1g-Plastic Bottle with Glass Insert, 100mg-Plastic Bottle with Glass Insert

Specification

Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	175.0 to 179.0 deg-C

Data of Reference

mp	177°C
λmax	304(MeOH)(Lit.)

References

Reaxys-RN	768704
PubChem SID	125307796
Merck Index(14)	10193
RTECS#	TL1425000

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H302 :Harmful if swallowed. H315 :Causes skin irritation. H319 :Causes serious eye irritation. H336 :May cause drowsiness and dizziness. H362 :May cause harm to breast-fed children.
Precautionary Statements	P201 :Obtain special instructions before use. P260 :Do not breathe. P263 :Avoid contact during pregnancy/while nursing. P264 :Wash hands thoroughly after handling. P270 :Do not eat, drink or smoke when using this product. P271 :Use only outdoors or in a well-ventilated area. P280 :Wear protective gloves/eye protection/face protection. P301+P312+P330 :IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. P302+P350 :IF ON SKIN: Gently wash with plenty of soap and water. P304+P340 :IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305+P351+P338 :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 :IF exposed or concerned: Get medical advice/attention. P332+P313 :If skin irritation occurs: Get medical advice/attention. P337+P313 :If eye irritation persists: Get medical advice/attention. P362 :Take off contaminated clothing and wash before reuse. P403+P233 :Store in a well-ventilated place. Keep container tightly closed. P405 :Store locked up. P501 :Dispose of contents/container through a waste management company authorized by the local government

Application

Pharmacology study

References

Differences in pharmacological profiles of a new generation of benzodiazepine and non-benzodiazepine hypnotics
- G. Perrault, E. Morela, D. J. Sangera, B. Zivkovic, Eur. J. Pharmacol. 1990, 187, 487.
Zopiclone: an update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia
- S. Noble, H. D. Langtry, H. M. Lamb, Drugs 1998, 55, 277.
In vitro and in vivo inhibition by zopiclone of benzodiazepine binding to rodent brain receptors
- J. C. Blanchard, A. Boireau, C. Garret, L. Julou, Life Sci. 1979, 24, 2417.