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Guanidinylation [C-X Bond Formation]
The guanidine structure is a basic skeleton of bioactive substances. For instance, saxitoxin and tetrodotoxin derived from puffer toxin, and batzelladine A as an HIV inhibitor in sea sponge are known as compounds bearing a guanidino group. Also pharmaceutical compounds like antimalarial and antimicrobial agents often have guanidine structure. Guanidinylation reagents are used for the synthesis of guanidine derivertives in the drug discovery field.1)
The brochure is in the link below.
- 1-Amidinopyrazole Hydrochloride
- Sodium Dicyanamide
- 1,2,4-Triazole-1-carboximidamide Hydrochloride