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4-Aminobutyric Acid
(CAS Number:56-12-2 Product Number:A0282)

Structure

4-Aminobutyric Acid
Synonym GABA

General Information

Product Number A0282

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Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C4H9NO2=103.12
CAS Number 56-12-2
Related CAS Number
MDL Number MFCD00008226
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Specification

Purity(Nonaqueous Titration) min. 99.0 %
Solubility in Water almost transparency

References

Beilstein 4(3)1316
Reaxys-RN 906818
PubChem SID 87561936
Merck Index(14) 430
RTECS# ES6300000

Transport Information

HS Number 2922.49.4050

Application

GABA: A Major Inhibitory Neurotransmitter in Nervous System

4-Aminobutyric acid (γ-aminobutyric acid or GABA) is a major inhibitory neurotransmitter in nervous system, the first report by Hayashi et al. in 1950s. GABA is present not only in the central nervous system but also in the peripheral nervous system. GABA plays the principal role in modulating neuronal excitability throughout the nervous system. Moreover, GABA is involved in a variety of biological functions such as proliferation, differentiation, migration and growth of neurons. GABA functions appear to be triggered by binding of GABA to its ionotropic receptors (GABAA and GABAC) which are ligand-gated chloride channels, and its metabotropic receptors GABAB which are coupled to G-proteins.

References

PubMed Literature

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