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(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate
(CAS RN:893413-42-8 Product Number:C3461)

Structure

(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate
Synonym TPTDP

General Information

Product Number C3461

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C18H27ClF6N6OP2=554.84
CAS RN 893413-42-8
Related CAS RN
MDL Number MFCD14560589
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%

References

Reaxys-RN 12838887
PubChem SID 354335200

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2933.99.8290

Application

Condensing Agent

Condensing Agent

Experimental procedure:
1 (0.5 g, 2.75 mmol) is dissolved in CH2Cl2 (5 mL). 2 (2.2 g, 5.5 mmol), DIEA (1.9 mL, 1.1 mmol), and TPTDP (3.057 g, 5.5 mmol) are dissolved in CH2Cl2 (5 mL). After 2 is dissolved, it is added to the solution of 1 and stirred overnight. The mixture is concentrated under reduced pressure. The methyl ester is removed using 1 mol/L LiOH (30 mL)/MeOH (70 mL) for 4 h. The mixture is acidified by the addition of 3 mol/L HCl (30 mL). MeOH is then removed by evaporation. Ethyl acetate (50 mL) and saturated NaCl (100 mL) is added, followed by extraction 4 times with ethyl acetate (50mL). The organic fractions are combined and the ethyl acetate is concentrated under reduced pressure. The crude is purified by RP-HPLC (CH3CN:H2O:TFA) to give 3 as a white solid.

References

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