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5-Fluoro-1-(tetrahydro-2-furfuryl)uracil
(CAS Number:17902-23-7 Product Number:F0635)

Structure

5-Fluoro-1-(tetrahydro-2-furfuryl)uracil
Synonym Tegafur

General Information

Product Number F0635

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Purity/Analysis Method >98.0%(HPLC)(N)
Storage Temperature
M.F. / M.W. C8H9FN2O3=200.17
CAS Number 17902-23-7
Related CAS Number
MDL Number MFCD00012351
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 167.0 to 171.0 deg-C

References

Beilstein 24(5)6,285
Reaxys-RN 525766
PubChem SID 87559743
Merck Index(14) 9112
RTECS# YR0450000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H300
  • :Fatal if swallowed.
  • H373
  • :May cause damage to Liver, Bone Marrow through prolonged or repeated exposure.
Precautionary Statements
  • P260
  • :Do not breathe dust, fume, mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P314
  • :Get medical advice or attention if you feel unwell.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2811
Class 6.1
Packing Group II
HS Number 2933.59.9500

Application

Tegafur: A Prodrug of an Active Antitumor 5-FU

Tegafur is a prodrug that is metabolized by cytochrome P 450 to an active antitumor 5-FU [F0151]. Tegafur is often used as combined agents such as UFT (tegafur and uracil [U0013] at a molar ratio of 1:4) or S-1 (tegafur, gimeracil [C2243] and potassium oxonate [O0164] at a molar ratio of 1:0.4:1) to increase the plasma and tumor 5-FU concentrations. Determination of the combined agents in plasma is important to evaluate the safety and efficacy of them. (The product is for research purpose only.)

References

PubMed Literature

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