Home >   Products   >  Advanced Search

Glycine Ethyl Ester Hydrochloride
(CAS Number:623-33-6 Product Number:G0102)

Structure

Glycine Ethyl Ester Hydrochloride
Synonym H-Gly-OEt·HCl

General Information

Product Number G0102

* Items available from stock in Japan will be delivered in 10 business days.
* Please contact us if you need further information.
(Sales Dept Tel: 800-423-8616 / 503-283-1681 E-mail: Sales-US@TCIchemicals.com)
* To send your quote request for bulk quantities, please click on the “Request Bulk Quotation” button.

Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C4H9NO2·HCl=139.58
CAS Number 623-33-6
Related CAS Number
MDL Number MFCD00012871
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 97.0 area%
Purity(Argentmetric Titration) min. 99.0 %
Solubility in Water almost transparency
Water max. 1.0 %
Glycine max. 0.5 %

References

Beilstein 4,340
Reaxys-RN 3594034
PubChem SID 87570308
RTECS# MC0525000

Transport Information

HS Number 2922.49.4050

Application

Preparation of Ethyl Diazoacetate

Typical Procedure: A solution containing 140 g glycine ethyl ester hydrochloride (1 mol) in 250 mL water is placed in a 2 L four neck flask. 600 mL dichloromethane is added and the mixture is cooled to -5 ℃ under a nitrogen atmosphere. A solution containing 83 g sodium nitrite in 250 mL water is cooled to 0 ℃ and added with stirring to the reaction mixture. While keeping the reaction temperature below -9 ℃, 95 g 5% sulfuric acid is added dropwise to the reaction over a 3 minute period. After ten minutes addition stirring the reaction is transferred to a 2 L separatory funnel while cold. The isolated yellow-greenish organic phase is poured into a cooled 1 L 5% sodium carbonate solution, then placed into a separatory funnel and shaken. The isolated aqueous phase is extracted with 75 mL dichloromethane, dried over 15 g anhydrous sodium sulfate, and concentrated under reduced pressure (350 mmHg). Further concentration at 20 mmHg and a bath temperature of 35 ℃ gives 90~100 g (79~88%) yellow oily substance. The product is pure enough to be used for ordinary synthesizing purposes. It is explosive, and distillation under even reduced pressure is hazardous. *Ethyl diazoacetate is explosive and very toxic. Wear protective gloves, protective goggles, protective mask, and use a safety screen. Work in a well ventilated fume hood.

References

  • Org. Synth. 1963, Coll. Vol. 4, 424.

Page Top