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Glycine Ethyl Ester Hydrochloride
(CAS Number:623-33-6 Product Number:G0102)


Glycine Ethyl Ester Hydrochloride
Synonym H-Gly-OEt·HCl

General Information

Product Number G0102

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Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C4H9NO2·HCl=139.58
CAS Number 623-33-6
Related CAS Number
MDL Number MFCD00012871
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(HPLC) min. 97.0 area%
Purity(Argentmetric Titration) min. 99.0 %
Solubility in Water almost transparency
Water max. 1.0 %
Glycine max. 0.6 %


Beilstein 4,340
Reaxys-RN 3594034
PubChem SID 87570308
RTECS# MC0525000


Signal Word Warning
Hazard Statements
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear eye protection.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2922.49.4050


Preparation of Ethyl Diazoacetate

Typical Procedure: A solution containing 140 g glycine ethyl ester hydrochloride (1 mol) in 250 mL water is placed in a 2 L four neck flask. 600 mL dichloromethane is added and the mixture is cooled to -5 ℃ under a nitrogen atmosphere. A solution containing 83 g sodium nitrite in 250 mL water is cooled to 0 ℃ and added with stirring to the reaction mixture. While keeping the reaction temperature below -9 ℃, 95 g 5% sulfuric acid is added dropwise to the reaction over a 3 minute period. After ten minutes addition stirring the reaction is transferred to a 2 L separatory funnel while cold. The isolated yellow-greenish organic phase is poured into a cooled 1 L 5% sodium carbonate solution, then placed into a separatory funnel and shaken. The isolated aqueous phase is extracted with 75 mL dichloromethane, dried over 15 g anhydrous sodium sulfate, and concentrated under reduced pressure (350 mmHg). Further concentration at 20 mmHg and a bath temperature of 35 ℃ gives 90~100 g (79~88%) yellow oily substance. The product is pure enough to be used for ordinary synthesizing purposes. It is explosive, and distillation under even reduced pressure is hazardous. *Ethyl diazoacetate is explosive and very toxic. Wear protective gloves, protective goggles, protective mask, and use a safety screen. Work in a well ventilated fume hood.


  • Org. Synth. 1963, Coll. Vol. 4, 424.

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