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Mubritinib
(CAS Number:366017-09-6 Product Number:M3058)

Structure

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Mubritinib
Synonym TAK 165
Synonym (E)-4-[[4-[4-(1H-1,2,3-Triazol-1-yl)butyl]phenoxy]methyl]-2-[4-(trifluoromethyl)styryl]oxazole

General Information

Product Number M3058

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C25H23F3N4O2=468.48
CAS Number 366017-09-6
Related CAS Number
MDL Number MFCD09954135
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Specification

Purity(HPLC) min. 98.0 area%
Melting point 158.0 to 162.0 deg-C

References

Reaxys-RN 13498857

Transport Information

HS Number 2934.99.4400

Application

Mubritinib: A Selective Inhibitor of the Human Epidermal Growth Factor Receptor 2 (HER2) Tyrosine Kinase

Small-molecule protein kinase inhibitors are widely used to elucidate cellular signaling pathways. Mubritinib (TAK 165) is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase. Reportedly, mubritinib specifically inhibits HER2 tyrosine kinase IC50 6 nmol/L and do not inhibit other types of tyrosine kinase up to 25,000 nmol/L.1) Several reports suggest HER2 expression in bladder cancer, renal cell carcinoma (RCC) and androgen-independent prostate cancer. However, the clinical development program for mubritinib as an anti-cancer drug was discontinued. (The product is for research purpose only.)

References

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