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OCT4 Activator

No.176(January 2018)
O0490
OAC1  (1)
OAC1 (1) was identified through high-throughput screening of a small molecule library as an OCT4-activating compound.1) 1 enhanced reprogramming efficiency of induced pluripotent stem (iPS) cells. Furthermore, 1 was used for direct-reprogramming of mouse fibroblasts into functional astrocytes.2)
1 also enhanced ex vivo expansion of human umbilical-cord blood hematopoietic stem and progenitor cells.3) Homeobox protein, HOXB4, is essential for the 1-mediated expansion.

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