Formyl group-containing compounds are important building blocks in organic synthesis since the formyl group can be transformed to other various functional groups. Aldehydes are the most typical formyl group-containing compound and are widely used as a substrate for carbon-carbon bond forming reactions such as the aldol reaction and the Wittig reaction.1-2) Also, their oxidation/reduction converts them to the related alcohols and carboxylic acids respectively, while the reductive amination is an efficient functional transformation of the formyl group into amines.3-5) As above reactions,the formyl group is a versatile precursor of organosynthetic reactions and a number of various formyl group introducing reagents have been developed.
Reagents for the formylation are classified into three types according to their reactivity and substrates: (1) electrophilic aromatic substitution, (2) reaction with carbon nucleophiles, and (3) direct formylation at oxygen or nitrogen atoms.
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Published TCIMAIL newest issue No.199