Acamprosate calcium is a synthetic compound with a chemical structural similar of the endogenous amino acid homotaurine [
A2602], and a structural analogue of the amino acid neurotransmitter γ-aminobutyric acid (GABA) [
A0282] and the amino acid neuromodulator taurine [
A0295]. The precise mechanism is not fully understood, but there is evidence to suggest that acamprosate may interact with glutamate and GABA, excitatory and inhibitory neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. Acamprosate calcium is widely used in the treatment of alcohol dependence in clinical. (The product is for research purpose only.)