Biochanin A

Reference

• 1) Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis
  • D. Lechner, S. Gibbons, F. Bucar, J. Antimicrob. Chemother. 2008, 62, 345.


Anwendung
Antimicrobial research / Antimicrobial activity potentiation

Reference

• Isoflavones As Potentiators of Antibacterial Activity
  • C. Morel, F.R. Stermitz, G. Tegos, K. Lewis, J. Agric. Food Chem. 2003, 51, 5677.


Anwendung
Studies of the Growth Inhibitory Effects of Biochanin A against Cancer Cells

References

• Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation
  • G. Peterson, S. Barnes, Prostate 1993, 22, 335.
• Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: a site-directed mutagenesis study
  • Y. C. Kao, C. Zhou, M. Sherman, C. A. Laughton, S. Chen, Environ. Health Perspect. 1998, 106, 85.
• Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells
  • C. Wang, M. S. Kurzer, Nutr. Cancer 1997, 28, 236.
• Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
  • S. Zhang, M. E. Morris, J. Pharmacol. Exp. Ther. 2003, 304, 1258.
• Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A
  • T. Gotoh, K. Yamada, H. Yin, A. Ito, T. Kataoka, K. Dohi, Cancer Sci. 1998, 89, 137.


Anwendung
Tyrosine Kinase Iinhibitor: Biochanin A

References

• 1)A review of the effects of plant estrogenic substances on animal reproduction
  • D. E. Samuel, Ohio J. Sci. 1967, 67, 308.
• 2)Biochanin A and formononetin content in red clover varieties at several maturity stages
  • W. Dedio, K. W. Clark, Can. J. Plant Sci. 1968, 48, 175.
• 3)Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones
  • H. Ogawara, T. Akiyama, S. Watanabe, N. Ito, M. Kobori, Y. Seoda, J. Antibiot. 1989, 42, 340.
• 4)Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
  • L. Wang, B. Waltenberger, E.-M. Pferschy-Wenzig, M. Blunder, X. Liu, C. Malainer, T. Blazevic, S. Schwaiger, J. M. Rollinger, E. H. Heiss, D. Schuster, B. Kopp, R. Bauer, H. Stuppner, V. M. Dirsch, A. G. Atanasov, Biochem. Pharmacol. 2014, 92, 73.
• 5)Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in vitro
  • P. Shen, M. H. Liu, T. Y. Ng, Y. H. Chan, E. L. Yong, J. Nutr. 2006, 136, 899.
• 6)Biochanin A promotes osteogenic but inhibits adipogenic differentiation: Evidence with primary adipose-derived stem cells
  • S.-J. Su, Y.-T. Yeh, S.-H. Su, K.-L. Chang, H.-W. Shyu, K.-M. Chen, H. Yeh, Evid. Based Complement. Alternat. Med. (eCAM) 2013, 2013, 846039.


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