L-Norvaline

Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.¹⁾ Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”¹⁾ and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.^2,3)). Cogerminants are compounds that do not have germination-stimulating activity in themselves but stimulate germination when combined with other compounds. L-Norvaline has been reported to act as a cogerminant in combination with taurocholate (T0808) for Clostridium difficile spore.⁴⁾ For Clostridium frigidicarnis spores, the amino acid was demonstrated to act as a cogerminant when used with L-lactate (L0165) and cogerminants, NaHCO₃ (S0561) and L-cysteine (C0515).⁵⁾
(The product is for research purpose only.)