Stage-Specific Embryonic Antigens (SSEAs) are glycan antigens known to vary in their expression levels across the stages of embryonic development and cell differentiation.¹⁾
SSEA-1, also called Lewis X Antigen, is expressed on the surface of mouse embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) and is often used as a mouse pluripotent stem cell marker. SSEA-3 and SSEA-4 are the Globo-series Glycosphingolipids Gb₅ and SialylGb₅, and are localized on the cell surface of human embryonic cancer cells (EC cells), ES cells, iPS cells and Muse (Multilineage-differentiating Stress Enduring) cells, where they are used as markers. SSEA-4 has also been shown to be overexpressed in many cancers, suggesting a correlation with disease progression.²⁾
TCI has a wide line-up of mouse monoclonal antibodies, synthetic glycans and glycan conjugates for SSEA-3, SSEA-4, SSEA-1.