Published TCIMAIL newest issue No.200
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Hara Reagent: A Stable Fluorinating Reagent with Ease of Handling
IF5-Pyridine-HF (1), which was first reported by Hara et al., is a novel fluorinating reagent. Pentafluoroiodide (IF5) is a strong fluorination liquid agent, but it reacts with moisture in the air and decomposes, generating HF. 1 is a crystalline solid reagent which makes it easier to handle, and can be used as an alternative reagent to IF5. 1 can be applied to various fluorination reactions of sulfides and thioacetals.1-4) In addition, 1 iodofluorinates alkenes with streo- and regioselectivity.5)
Related Products
- P2140
- IF5-Pyridine-HF (*This product is discontinued.)
References
- 1) IF5–pyridine–HF: air- and moisture-stable fluorination reagent
- 2) Synthesis of fluoromethyl ethers and fluoromethyl esters by the reaction of the corresponding methylthiomethyl ethers and methylthiomethyl esters with IF5-pyridine-HF
- 3) Synthesis of trifluoromethyl ethers and difluoro(methylthio)methyl ethers by the reaction of dithiocarbonates with IF5-pyridine-HF
- 4) Synthesis of glycosyl fluorides from (phenylthio)glycosides using IF5-pyridine-HF
- 5) Iodofluorination of Alkenes Using IF5–Pyridine–HF
- 6) Iodoazidation of Alkenes by Using Iodine Pentafluoride-Pyridine-Hydrogen Fluoride and Trimethylsilyl Azide
- 7) Stereoselective synthesis of iodofluoroalkenes by iodofluorination of alkynes using IF5-pyridine-HF
- 8) Trifluorination of sulfides and dithioketals using IF5-pyridine-HF
