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Published TCIMAIL newest issue No.198
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CAS RN: 54-62-6 | Product Number: A0410
Aminopterin
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 4-Aminofolic Acid
- 4-Amino-PGA
- 4-Aminopteroyl-L-glutamic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€57.00
|
1 | 14 |
|
| 100MG |
€185.00
|
Contact Us | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Product Number | A0410 |
Purity / Analysis Method 
|
>97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__0N__8O__5 = 440.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54-62-6 |
| Reaxys Registry Number | 69045 |
| PubChem Substance ID | 125308158 |
| Merck Index (14) | 472 |
| MDL Number | MFCD00036692 |
Specifications
| Appearance | White to Amber powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +18.0 to +22.0 deg(C=1、0.1mol/LNaOH sol.)(calcd.on anh.substance) |
| Water | 3.0 to 10.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 222 °C(dec.) |
| Specific Rotation | 20° (C=1,0.1mol/L NaOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-209-9 |
| RTECS# | MA1050000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2933599590 |
Application
Aminopterin: A Dihydrofolic Acid Reductase (DHFR) Inhibitor
Aminopterin, an amino derivative of folic acid [F0043], is a dihydrofolic acid reductase (DHFR) inhibitor. DHFR is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using nicotinamide adenine dinucleotide phosphate (NADPH) as electron donor, and a key enzyme in the synthesis of thymidylate and DNA. The inhibition causes the depletion of nucleotide precursors and inhibition of DNA. Aminopterin used to use as an antineoplastic agent in the treatment of leukemia. In the 1950’s, a less potent but less toxic methotrexate [M1664] began to replace in clinical use. (The product is for research purpose only.)
References
- Inhibition of dihydrofolic acid reductase by aminopterin and amethopterin
- M. J. Osborn, M. Freeman, F. M. Huennekens, Proc. Soc. Exp. Biol. Med. 1958, 97, 429.
- The effect of a folic acid antagonist (aminopterin) on transplantable lymphoid leukemias in mice
- Similar differential for total polyglutamylation and cytotoxicity among various folate analogs in human and murine tumor cells in vitro
- Metabolism of the diaminoantifolates: biosynthesis and pharmacology of the 7-hydroxyl and polyglutamyl metabolites of methotrexate and related antifolates (a review)
- Cancer research: from folate antagonism to molecular targets (a review)
PubMed Literature
Documents
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