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CAS RN: 665-66-7 | Product Number: A0588
1-Adamantanamine Hydrochloride
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Purity: >99.0%(T)
Synonyms:
- 1-Aminoadamantane Hydrochloride
- Amantadine Hydrochloride
- 1-Adamantylamine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
€34.00
|
3 | ≥100 |
|
|
| 250G |
€211.00
|
2 | 23 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | A0588 |
Purity / Analysis Method 
|
>99.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__7N·HCl = 187.71 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 665-66-7 |
| Related CAS RN
|
768-94-5 |
| Reaxys Registry Number | 4198854 |
| PubChem Substance ID | 87562172 |
| MDL Number | MFCD00074723 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Purity(Argentometric Titration) | min. 99.0 % |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 360 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 211-560-2 |
| RTECS# | AU4375000 |
Transport Information:
| HS Number | 2921309960 |
Application
1-Adamantanamine Hydrochloride: A Dopamine Receptor Agonist and an Anti-Influenza A Virus Agent
1-Adamantanamine hydrochloride and its free base [A2318] are dopamine receptor agonists and anti-influenza A virus agents, similarly rimantadine hydrochloride [R0070]. 1-Amantadine was originally developed as an antiviral agent. One day, a single patient noticed relief in her Parkinson’s disease symptoms after taking amantadine for a flu infection, and this observation led to a new drug indication.1)
These mechanisms of action are not fully understood. However, there is evidence to suggest that 1-adamantanamine act as a dopamine receptor agonist by enhancing the synthesis and release of dopamine from nerve cells and delaying the reuptake into synaptic vesicles.2,3)
In addition, 1-adamantanamine inhibits the replication of influenza A viruses by preventing the release of infectious viral RNA into the host cell nucleus by interfering with the function of the transmembrane of the viral M2 protein.4,5) (The product is for research purpose only.)
These mechanisms of action are not fully understood. However, there is evidence to suggest that 1-adamantanamine act as a dopamine receptor agonist by enhancing the synthesis and release of dopamine from nerve cells and delaying the reuptake into synaptic vesicles.2,3)
In addition, 1-adamantanamine inhibits the replication of influenza A viruses by preventing the release of infectious viral RNA into the host cell nucleus by interfering with the function of the transmembrane of the viral M2 protein.4,5) (The product is for research purpose only.)
References
- 1)Amantadine: The journey from fighting flu to treating Parkinson disease (a review)
- 2)Amantadine (a review)
- 3)Renaissance of amantadine in the treatment of Parkinson's disease (a review)
- 4)Influenza virus M2 protein has ion channel activity
- 5)Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
- 6)Amantadine (a review on the nomenclature, synthesis, reactions, stability, physical properties, and methods of detection)
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