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CAS RN: 661489-23-2 | Product Number: A2982
(E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride
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Purity: >98.0%(N)
Synonyms:
- (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€64.00
|
1 | 2 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A2982 |
Purity / Analysis Method 
|
>98.0%(N) |
| Molecular Formula / Molecular Weight | C__1__1H__1__2N__2·HCl = 208.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 661489-23-2 |
| Reaxys Registry Number | 11416007 |
| PubChem Substance ID | 354334826 |
| MDL Number | MFCD18711816 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 300 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| HS Number | 2926907090 |
Application
A Key Synthetic Intermediate of Rilpivirine
This product is a key synthetic intermediate of rilpivirine which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of HIV.
References
- Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate
- Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
- d. P. R. Schils, J. J. M. Willems, B. P. A. M. J. Medaer, E. T. J. Pasquier, J. Heeres, R. G. G. Leenders, J. E. G. Guillemont, P. A. J. Janssen, World Intellectual Property Organization WO 2004/016581 A1.
- A validated stability indicating HPLC assay method for rilpivirine HCl in bulk drug
Application
A Synthetic Building Block of Rilpivirine
This compound is a key synthetic building block of rilpivirine [CAS: 500287-72-9] which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV infection.
References
- Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate
- A validated stability indicating HPLC assay method for rilpivirine HCl in bulk drug
PubMed Literature
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