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Published TCIMAIL newest issue No.199
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CAS RN: 20350-15-6 | Product Number: B3820
Brefeldin A
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Purity: >98.0%(HPLC)
Synonyms:
- γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid λ-Lactone
- Ascotoxin
- Cyanein
- Decumbin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€119.00
|
1 | 22 |
|
| 50MG |
€380.00
|
Contact Us | 9 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B3820 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__4O__4 = 280.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20350-15-6 |
| Reaxys Registry Number | 25191 |
| PubChem Substance ID | 468590501 |
| Merck Index (14) | 1369 |
| MDL Number | MFCD12913297 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C |
| Specific Rotation | 93° (C=2,MeOH) |
| Maximum Absorption Wavelength | 215 nm (EtOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GY8410000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2932209090 |
Application
Autophagy research / Mitophagy research
References
- Erythroleukemia cells acquire an alternative mitophagy capability
- Discovery of Atg5/Atg7-independent alternative macroautophagy
Application
CRISPR Genome Editing / Research on regenerative medicine
Brefeldin A enhances CRISPR-mediated homology-directed repair (HDR) efficiency.
Reference
- Small molecules enhance CRISPR genome editing in pluripotent stem cells
Application
Brefeldin A: A Macrolide Lactone Antibiotic used as an Inhibitor of Protein Trafficking and Secretion
Brefeldin A (BFA) is a natural fungal macrolide lactone antibiotic. Studies has demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. Therefore, BFA has been used as a tool to inhibit protein secretion and study the secretory pathway, effects of BFA on Golgi apparatus and other subcellular systems.
References
- Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
- Brefeldin A: insights into the control of membrane traffic and organelle structure (a review)
- Brefeldin A: deciphering an enigmatic inhibitor of secretion (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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