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CAS RN: 179688-29-0 | Product Number: B4270
6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone
- 6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
- 6,7-Bis(2-methoxyethoxy)-4-hydroxyquinazoline
- 6,7-Bis(2-methoxyethoxy)-4-quinazolinol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€24.00
|
Ships within 3 weeks after ordering | 5 |
|
|
| 5G |
€85.00
|
1 | 15 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | B4270 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__8N__2O__5 = 294.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 179688-29-0 |
| Reaxys Registry Number | 10087641 |
| PubChem Substance ID | 253660263 |
| MDL Number | MFCD02678087 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 190.0 to 194.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 192 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
A Key Synthetic Intermediate of Erlotinib
This product is a key synthetic intermediate of erlotinib which is a receptor tyrosine kinase inhibitor acting on the epidermal growth factor receptor (EGFR), such as gefitinib [G0546].
References
- Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib
- Improved Synthesis of Gefitinib and Erlotinib Hydrochloride-Anticancer Agents
- Modified Synthesis of Erlotinib Hydrochloride
- Separation and determination of process-related impurities of erlotinib using reverse-phase HPLC with a photo-diode array detector
PubMed Literature
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