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CAS RN: 63659-19-8 | Product Number: B4474
Betaxolol Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
€97.00
|
1 | 16 |
|
|
| 250MG |
€333.00
|
1 | 23 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | B4474 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__9NO__3·HCl = 343.89 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 63659-19-8 |
| Related CAS RN
|
63659-18-7 |
| Reaxys Registry Number | 5182512 |
| PubChem Substance ID | 253662283 |
| Merck Index (14) | 1182 |
| MDL Number | MFCD00242959 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
| Solubility (slightly sol. in) | Acetone |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 264-384-3 |
| RTECS# | UA9823000 |
Transport Information:
| HS Number | 2922500090 |
Application
Betaxolol hydrochloride: A Selective β1-Adrenoceptor Antagonist with Ca2+ Channel-Blocking Activity.
Betaxolol hydrochloride is a selective β1-adrenoceptor antagonist with Ca2+ channel-blocking activity. Betaxolol hydrochloride also has been reported as a retinal neuroprotective agent. It is used for the treatment of hypertension and glaucoma. (The product is for research purpose only.)
References
- Synthesis of a series of compounds related to betaxolol, a new β1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases
- Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension
- Betaxolol, a β1-adrenoceptor antagonist, has an affinity for L-type Ca2+ channels
- In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent
- Topically applied betaxolol attenuates ischemia-induced effects to the rat retina and stimulates BDNF mRNA
- Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization
PubMed Literature
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