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CAS RN: 202189-78-4 | Product Number: B5392
Bilastine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-[4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
€203.00
|
1 | ≥60 |
|
|
| 1G |
€548.00
|
Contact Us | 10 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | B5392 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__3__7N__3O__3 = 463.62 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 202189-78-4 |
| Reaxys Registry Number | 13851185 |
| PubChem Substance ID | 354335500 |
| MDL Number | MFCD09837814 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 199.0 to 203.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 202 °C |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| HS Number | 2933399999 |
Application
Bilastine: A Selective Histamine H1 Receptor Antagonist
Bilastine is a selective histamine H1 receptor antagonist. On the other hand, the results of studies on bilastine confirmed the lack of significant antagonism against not only histamine H2 and H3 receptors but also serotonin, bradykinin, leukotriene D4, calcium, muscarinic M3-receptors, α1-adrenoceptors, and β2-adrenoceptors. Furthermore, bilastine do not cause sedation or interact with cytochrome P 450. Therefore, bilastine is used as a second generation H1-antihistamine for the treatment of allergic rhinitis and chronic urticarial. For your reference, [P2382] is a synthetic intermediate of bilastine.(The product is for research purpose only.)
References
- Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist. Receptor selectivity and in vitro antihistaminic activity
- In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist
- Safety and efficacy of bilastine: a new H1-antihistamine for the treatment of allergic rhinoconjunctivitis and urticarial (a review)
- Histamine and H1-antihistamines: Celebrating a century of progress (a review)
- Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method
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