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Published TCIMAIL newest issue No.199
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CAS RN: 877399-00-3 | Product Number: B5682
(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
![Chemical Structure of (R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine](/medias/B5682.jpg?context=bWFzdGVyfHJvb3R8NTIwOTd8aW1hZ2UvanBlZ3xhREl4TDJobE55ODRPVEl3TXprNU1ESXdNRFl5TDBJMU5qZ3lMbXB3Wnd8OWUyMDBjOGNmMDIxNWY0YjdkMzFkMmJkYzJhZjMxNWY0MmVjY2ZjZDZhNjRjMjM1MTY0MGVkMGEyY2QyMDRkNA "(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine")
![Thumbnail of (R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine](/medias/B5682.jpg?context=bWFzdGVyfHJvb3R8MTU4OTd8aW1hZ2UvanBlZ3xhREV5TDJnM1pDODRPVE16T0RFeU56azNORGN3TDBJMU5qZ3lMbXB3Wnd8ZjAzMDdiODg1YTkwM2UyMzk3YTM3OGE5NGRiMmIwOWU0MDZkMTg1NmJjYmRmMTI0MmM0NjI3ZjU2YWQwZDkxNA)
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![(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine")
Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€80.00
|
1 | 3 |
|
| 5G |
€302.00
|
Contact Us | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B5682 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__0BrCl__2FN__2O = 380.04 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 877399-00-3 |
| Reaxys Registry Number | 12134679 |
| PubChem Substance ID | 354335323 |
| MDL Number | MFCD18207061 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Specific rotation(value) | -64.0 to -70.0 deg(C=1, CHCL3) |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 108.0 to 113.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 109 °C |
| Specific Rotation | -67° (C=1,CHCl3) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933399999 |
Application
A Synthetic Intermediate of Tyrosine Kinase Inhibitors
This product has been used as a synthetic intermediate of tyrosine kinase inhibitors, such as crizotinib (PF-02341066).
References
- Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
- Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)
- Synthesis of a Crizotinib Intermediate via Highly Efficient Catalytic Hydrogenation in Continuous Flow
Application
A Key Synthetic Intermediate of Crizotinib
Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
References
- Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
- Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)
PubMed Literature
Documents
Product Articles
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Safety Data Sheet (SDS)
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Specifications
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