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CAS RN: 130-26-7 | Product Number: C0187
5-Chloro-8-hydroxy-7-iodoquinoline
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Purity: >97.0%(T)
Synonyms:
- Clioquinol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
€24.00
|
2 | 8 |
|
|
| 250G |
€145.00
|
1 | 2 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | C0187 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__9H__5ClINO = 305.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| CAS RN | 130-26-7 |
| Reaxys Registry Number | 153637 |
| PubChem Substance ID | 87565356 |
| SDBS (AIST Spectral DB) | 1606 |
| Merck Index (14) | 5031 |
| MDL Number | MFCD00006787 |
Specifications
| Appearance | Light yellow to Brown to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 204-984-4 |
| RTECS# | VC5075000 |
Transport Information:
| HS Number | 2933499090 |
Application
Clioquinol: A Metal-Chelating Antimicrobial Agent with Neuroprotective Properties
Clioquinol was first developed in 1930s as a topical antiseptic and an oral an oral intestinal amebicide. In the early 1970s, clioquinol was withdrawn from the pharmaceutical market as an oral agent due to its association with subacute myelooptic neuropathy (SMON). Recently, clioquinol has been reported as a metal-chelating antimicrobial agent with neuroprotective properties. Metal chelation is a potential therapeutic strategy for Alzheimer's disease (AD) because zinc and copper are involved in the deposition and stabilization of β-amyloid plaques, and chelating agents can dissolve amyloid deposits in vitro and in vivo. (The product is for research purpose only.)
References
- Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
- Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders
- Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse
- Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice
PubMed Literature
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