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Published TCIMAIL newest issue No.198
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CAS RN: 124-87-8 | Product Number: C0375
Picrotoxin (Picrotoxinin + Picrotin)
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Purity: >94.0%(HPLC)
Synonyms:
- Cocculin (Picrotoxinin + Picrotin)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€62.00
|
1 | 21 |
|
| 5G |
€237.00
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C0375 |
| Purity / Analysis Method | >94.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__0H__3__4O__1__3 = 602.59 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 124-87-8 |
| PubChem Substance ID | 87565507 |
| SDBS (AIST Spectral DB) | 10888 |
| Merck Index (14) | 7415 |
| MDL Number | MFCD00074824 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 94.0 %(Picrotoxinin and Picrotin mixture) |
Properties (reference)
| Melting Point | 200 °C |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 204-716-6 |
| RTECS# | TJ9100000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2939799090 |
Application
Picrotoxin: A Natural Sesquiterpene Antagonist of GABAA Receptors
Picrotoxin is a sesquiterpene that occurs naturally in the fruit of the Anamirta cocculus which a wild woody climber, distributed throughout India as well as South-East Asia. Picrotoxin is a mixture of two compounds, picrotoxinin and picrotin. Of the two compounds, picrotoxinin is the active ingredient. Picrotoxinin is a naturally occurring poison that a noncompetitive antagonist of GABAA receptors (GABARs), the primary mediators of inhibitory neurotransmission in the nervous system. Picrotoxinin prevents ion flow through the chloride channel activated by GABA in the GABAR, a member of the cys-loop, ligand-gated ion channel superfamily. (The product is for research purpose only.)
References
- Picrotoxin-like channel blockers of GABA receptors (a review)
PubMed Literature
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