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Published TCIMAIL newest issue No.198
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CAS RN: 5116-24-5 | Product Number: D6190
2'-Deoxy-5-(hydroxymethyl)uridine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- α-Hydroxythymidine
- 5-Hydroxymethyl-2'-deoxyuridine
- 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€136.00
|
Contact Us | 1 |
|
| 200MG |
€435.00
|
Contact Us | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D6190 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2O__6 = 258.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 5116-24-5 |
| Reaxys Registry Number | 31615 |
| MDL Number | MFCD00047489 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 179 °C |
GHS
Related Laws:
| EC Number | 225-848-0 |
| RTECS# | YU7600000 |
Transport Information:
| HS Number | 2934999090 |
Application
2'-Deoxy-5-(hydroxymethyl)uridine: A Base-Modified 2’-Deoxynucleoside Used in Oxidative Stress and Cancer Studies
2'-Deoxy-5-(hydroxymethyl)uridine is a base-modified 2’-deoxynucleoside with anticancer and antiviral activities.1,2) It also acts as a diagnostic biomarker for oxidative stress in mammalian cells.3,4) Therefore, it has been reported to be used as an indicator of cancer. (The product is for research purpose only.)
References
- 1) Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogs
- 2) Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
- 3) Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running
- 4) The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer (a review)
Product Articles
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