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Published TCIMAIL newest issue No.198
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CAS RN: 54350-48-0 | Product Number: E1293
Etretinate
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Purity: >98.0%(HPLC)
Synonyms:
- Ethyl all-trans-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate
- all-trans-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€69.00
|
Contact Us | 11 |
|
| 250MG |
€241.00
|
Contact Us | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1293 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__0O__3 = 354.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 54350-48-0 |
| Reaxys Registry Number | 2225606 |
| PubChem Substance ID | 468591705 |
| Merck Index (14) | 3892 |
| MDL Number | MFCD00866624 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 103.0 to 107.0 °C |
Properties (reference)
| Melting Point | 105 °C |
| Maximum Absorption Wavelength | 360 nm (H__2O) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ether, Acetone |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P273 : Avoid release to the environment. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 259-119-3 |
| RTECS# | RA6620000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2918999090 |
Application
Etretinate: A Synthetic Retinoic Acid Derivative that is a Prodrug of Acitretin
Etretinate is a retinoic acid (vitamin A acid) [R0064] derivative that is a prodrug of acitretin [A3097]. Etretinate is used for the treatment of severe psoriasis and other dyskeratoses, but the precise mechanism of action of it is not fully understood. However, the pharmacological profile of etretinate suggests that it acts by normalizing pathological changes in epidermal and dermal skin, particularly inhibiting hyperkeratinization and cell differentiation. In addition, etretinate reportedly has teratogenic potential. (The product is for research purpose only.)
References
- Etretinate. A review of its pharmacological properties and therapeutic efficacy in psoriasis and other skin disorders (a review)
- Recent progress in commercial retinoids and carotenoids (a review)
- Modulations of elastin expression and cell proliferation by retinoids in cultured vascular smooth muscle cells
- Comparative teratogenicity of nine retinoids in the rat
- Determination of isotretinoin or etretinate and their major metabolites in human blood by reversed-phase high-performance liquid chromatography
Product Documents (Note: Some products will not have analytical charts available.)
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