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CAS RN: 152044-54-7 | Product Number: E1378

Epothilone B


Purity: >95.0%(HPLC)
Synonyms:
Product Documents:
5MG
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25MG
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Product Number E1378
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__2__7H__4__1NO__6S = 507.69 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Heat Sensitive
CAS RN 152044-54-7
Reaxys Registry Number 7556514
PubChem Substance ID 468591745
Merck Index (14) 3628
MDL Number

MFCD02101921

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 95.0 area%
Specific rotation [a]20/D -40.0 to -44.0 deg (C=0.2, methanol)
Elemental analysis(Carbon) 62.50 to 65.00 %
NMR confirm to structure
Properties (reference)
Melting Point 94 °C
Specific Rotation -36° (C=0.2,MeOH)
Maximum Absorption Wavelength 249(MeOH) nm
GHS
Related Laws:
RTECS# JG6799500
Transport Information:
Application
Epothilone B: A Microtubule Inhibitor

Epothilone B, a natural macrolide compound, is a microtubule inhibitor belonging to a class of antineoplastic agents. Epothilone B was originally isolated from the cellulose-degrading myxobacteria Sorangium cellulosum. Epothilone B has a mode of action analogous to that of paclitaxel [P1632]. It binds directly to β-tubulin subunits on microtubules, stabilizing microtubules. It blocks cells in the mitotic phase of the cell division cycle, leading to cell death. Epothilone B has poor metabolic stability and unfavorable pharmacokinetics.1-4) Therefore, its analogs (e.g. Ixabepilone; BMS-247550) were synthesized and used in clinical.4) (The product is for research purpose only.)

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