Indometacin Farnesil: A Prodrug of the Non-Steroidal Anti-Inflammatory Drug Indomethacin
Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) indomethacin [
I0655], designed to reduce the occurrence of side-effects in the gastrointestinal tract. When indometacin farnesil is administered orally, it is absorbed through the gastrointestinal tract as unchanged drug which is mildly injurious to the tract. Indometacin farnesil is metabolized to indomethacin, the active form, in the liver and kidney, and this indomethacin inhibits prostaglandin biosynthesis by inhibiting cyclooxygenase (COX). (The product is for research purpose only.)