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CAS RN: 75706-12-6 | Product Number: L0250
Leflunomide
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 5-Methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€51.00
|
1 | ≥40 |
|
| 1G |
€183.00
|
5 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0250 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__2H__9F__3N__2O__2 = 270.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 75706-12-6 |
| Reaxys Registry Number | 4323174 |
| PubChem Substance ID | 160871382 |
| Merck Index (14) | 5432 |
| MDL Number | MFCD00867593 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 166.0 to 170.0 °C |
Properties (reference)
| Melting Point | 168 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 27 mg/l 25 °C |
| Solubility (soluble in) | Methanol, Acetone, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | NY2354200 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2934999090 |
Application
Leflunomide: A Prodrug of Immunoregulatory Agent, Teriflunomide
Leflunomide is a prodrug of teriflunomide [T3287] which has two activites: inhibition of pyrimidine nucleotide synthesis and interference with tyrosine phosphorylation. More specifically, it inhibits the enzymic activity of dihydroorotate dehydrogenase (DHO-DHase) which catalyzes the fourth step in the biosynthesis of pyrimidine, and tyrosine kinases which transfer a phosphate group from ATP to a protein in a cell. Leflunomide reduces the proliferation of T and B immune cells that are active in multiple sclerosis (MS). For your reference, [C3217] is a synthetic intermediate. (The product is for research purpose only.)
References
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase
- Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-κB activation and gene expression
- S. K. Manna, B. B. Aggarwal, J. Immunol. 1999, 162, 2095.
- Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
- Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
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