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Published TCIMAIL newest issue No.199
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CAS RN: 73-31-4 | Product Number: M1105
Melatonin
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Purity: >98.0%(HPLC)(N)
Synonyms:
- N-Acetyl-5-methoxytryptamine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€16.00
|
11 | ≥100 |
|
| 5G |
€34.00
|
16 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M1105 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__3H__1__6N__2O__2 = 232.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 73-31-4 |
| Reaxys Registry Number | 205542 |
| PubChem Substance ID | 87573071 |
| SDBS (AIST Spectral DB) | 13372 |
| Merck Index (14) | 5816 |
| MDL Number | MFCD00005655 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 117.0 to 120.0 °C |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 118 °C |
GHS
Related Laws:
| EC Number | 200-797-7 |
| RTECS# | AC5955000 |
Transport Information:
| HS Number | 2933998090 |
Application
Melatonin: A Regulator of a Wide Range of Physiological Processes
Melatonin is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm (24-hour cycles) with low levels during the day and elevated levels at night. Melatonin synchronizes both central and peripheral oscillators, allowing the temporal organization of biological functions by circadian rhythms. In addition, melatonin is remarkably functionally diverse with actions as a free radical scavenger and antioxidant, anti-inflammatory and immunoregulatory molecular, and as an oncostatic agent. Melatonin activates two high-affinity G protein-coupled receptors, termed MT1 and MT2, to exert beneficial effects during sleep. For your information, ramelteon [R0216] is a selective melatonin MT1 and MT2 receptor agonist. (The product is for research purpose only.)
References
- Melatonin: Pharmacology, Functions and Therapeutic Benefits (a review)
- Melatonin as an Antioxidant: Under Promises but Over Delivers (a review)
- Cancer metastasis: Mechanisms of inhibition by melatonin (a review)
- MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective (a review)
Application
Mitophagy research
References
- Melatonin Represses Mitophagy to Protect Mouse Granulosa Cells from Oxidative Damage
- Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS
- Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition
- Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition
- Melatonin Attenuates Traumatic Brain Injury-induced Inflammation: A Possible Role for Mitophagy
PubMed Literature
Documents
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