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CAS RN: 13614-98-7 | Product Number: M2288
Minocycline Hydrochloride
×
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€ 106,00
|
2 | 24 |
|
|
| 5G |
€ 337,00
|
1 | ≥60 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M2288 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__7N__3O__7·HCl = 493.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 13614-98-7 |
| Related CAS RN
|
10118-90-8 |
| Reaxys Registry Number | 4836328 |
| PubChem Substance ID | 160871228 |
| Merck Index (14) | 6202 |
| MDL Number | MFCD00083669 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -170 to -180 deg(C=0.5、0.1mol/L HCl) |
| Water | 4.3 to 8.0 % |
Properties (reference)
| Specific Rotation | -175° (C=0.5,0.1mL/L HCl) |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Dimethylformamide, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 237-099-7 |
| RTECS# | QI7630500 |
Transport Information:
| HS Number | 2941300000 |
Application
Biofilm research
Susceptibility of Actinobacillus actinomycetemcomitans, strain 310a, biofilm to minocycline has been reported.1) Adding 0.1 mg/mL of the antibiotic significantly inhibited the biofilm formation in the early phase, but not in the mature phase. Although adding 10 mg/L of the antibiotic reduced biofilm development in the early phase, it enhanced biofilm development in the mature phase.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures
- 1) Inhibition of Trypsin-Like Cysteine Proteinases (Gingipains) from Porphyromonas gingivalis by Tetracycline and Its Analogues
- The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin
- Neuroprotective and anti-human immunodeficiency virus activity of minocycline
- Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
- Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
- A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
- Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
Application
Gingipain inhibitor
Minocycline has been reported to inhibit gingipains, arginine-specific gingipains (HRgpA and RgpB), and lysine-specific gingipain (Kgp) from Porphyromonas gingivalis.1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
Application
Studies on Antibiotic Activity
References
Application
Neuroprotective Studies
References
PubMed Literature
Documents
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