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Published TCIMAIL newest issue No.199
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CAS RN: 70476-82-3 | Product Number: M3110
Mitoxantrone Dihydrochloride
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Purity: >97.0%(HPLC)
Synonyms:
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone Dihydrochloride
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthracene-9,10-dione Dihydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€46.00
|
1 | 39 |
|
| 100MG |
€125.00
|
2 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M3110 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__8N__4O__6·2HCl = 517.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 70476-82-3 |
| Related CAS RN
|
65271-80-9 |
| Reaxys Registry Number | 4835931 |
| PubChem Substance ID | 468592271 |
| Merck Index (14) | 6217 |
| MDL Number | MFCD00242943 |
Specifications
| Appearance | Dark green to Dark purple to Black powder to crystal |
| Purity(Argentometric Titration) | min. 95.0 % |
| Purity(HPLC) | min. 97.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 267 °C(dec.) |
| Maximum Absorption Wavelength | 660 nm (H__2O) |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Acetone, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H310 : Fatal in contact with skin. H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H351 : Suspected of causing cancer. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 274-619-1 |
| RTECS# | CB0386900 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2922500090 |
Application
Virus research
References
- Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection
- Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone
- Developing a Dynamic Pharmacophore Model for HIV-1 Integrase
- Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells
- Experimental antitumor activity of aminoanthraquinones
- Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
- Mechanism of Action of Topoisomerase II-Targeted Antineoplastic Drugs
- Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer
- Mechanism of action of mitoxantrone (a review)
- HPLC analysis of mitoxantrone in mouse plasma and tissues: Application in a pharmacokinetic study
- Mitoxantrone hydrochloride (a review on the description, synthesis, physical properties, stability, pharmacology, and detection)
Application
Mitochondria research
Reference
Application
Mitoxantrone Dihydrochloride: A Synthetic Anthracycline Antitumor Agent with Improved Tolerability
Mitoxantrone [M3133] and its dihydrochloride are synthetic anthracycline antitumor agents that are structurally similar to doxorubicin hydrochloride [D4193] and daunorubicin hydrochloride [D4532]. Mitoxantrones intercalate into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. .Mitoxantrones also inhibit DNA repair by inhibiting topoisomerase II which results in fragmentation of DNA. Mitoxantrones display an improved tolerability profile compared with doxorubicin and other anthracyclines, but cross-resistance with the anthracyclines has been demonstrated. (The product is for research purpose only.)
References
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