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Published TCIMAIL newest issue No.198
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CAS RN: 98-92-0 | Product Number: N0078
Nicotinamide
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Purity: >99.0%(T)(HPLC)
Synonyms:
- Niacinamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
16,00 €
|
14 | ≥100 |
|
| 500G |
58,00 €
|
8 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0078 |
Purity / Analysis Method 
|
>99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__6N__2O = 122.13 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 98-92-0 |
| Reaxys Registry Number | 383619 |
| PubChem Substance ID | 87573471 |
| SDBS (AIST Spectral DB) | 553 |
| Merck Index (14) | 6523 |
| MDL Number | MFCD00006395 |
Specifications
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 129.0 to 132.0 °C |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 129 °C |
| Boiling Point | 336 °C |
| Degree of solubility in water | 1,200 g/l 20 °C |
| Solubility (slightly sol. in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
| EC Number | 202-713-4 |
| RTECS# | QS3675000 |
Transport Information:
| HS Number | 2936290000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Cogerminants are compounds that do not have germination-stimulating activity in themselves but stimulate germination when combined with other compounds. Nicotinamide has been reported to act as a cogerminant for Clostridium tetani spores when used with L-lactate (L0165), L-methionine (M0099), and Na+.4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) The Germination of Spores of Clostuidium tetani
- Hypoglycaemic effects of antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats
Application
Reagent for diabetes mellitus model
References
PubMed Literature
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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