Maintenance Notice (4:00 AM November 1 - 9:30 AM November 1, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.199
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 28957-04-2 | Product Number: O0387
Oridonine
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
- (14R)-7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one
- (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€103.00
|
Contact Us | 4 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | O0387 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__8O__6 = 364.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 28957-04-2 |
| Reaxys Registry Number | 1691227 |
| PubChem Substance ID | 468592517 |
| MDL Number | MFCD00221762 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -57.0 to -61.0 deg (C=0.1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 252 °C |
| Maximum Absorption Wavelength | 237 nm (EtOH) |
GHS
Related Laws:
| RTECS# | NZ8177000 |
Transport Information:
| HS Number | 2932990090 |
Application
Oridonin: An Active Diterpene with NLRP3 Inhibitory Activity
Oridonin (or oridonine) is an active diterpene isolated from Rabdosia rubescens used as a traditional Chinese medicine. Oridonin has been reported to possess a broad range of biological activities including anti-inflammation, anti-bacterial, anti-neoplastic and neuroprotective effects. It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. Oridonin has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)
References
- Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics (a review)
- Discovery and development of natural product oridonin-inspired anticancer agents (a review)
- Therapeutic potential of oridonin and its analogs: from anticancer and antiinflammation to neuroprotection
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors (a review)
Documents
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.