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CAS RN: 484-12-8 | Product Number: O0426
Osthole
×
Purity: >98.0%(GC)
Synonyms:
- 7-Methoxy-8-(3-methyl-2-butenyl)coumarin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
€16.00
|
1 | ≥40 |
|
|
| 1G |
€47.00
|
1 | 18 |
|
|
| 5G |
€151.00
|
1 | 11 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | O0426 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__6O__3 = 244.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 484-12-8 |
| Reaxys Registry Number | 1288399 |
| PubChem Substance ID | 253662100 |
| Merck Index (14) | 6895 |
| MDL Number | MFCD00076049 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 82.0 to 86.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 84 °C |
| Maximum Absorption Wavelength | 322 nm (MeOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol |
GHS
Related Laws:
| RTECS# | GN7700000 |
Transport Information:
| HS Number | 2932209090 |
Application
Efflux pump inhibitor
References
- Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: Reversing the resistance against frontline antibacterial drugs
Application
A Crude Drug Ingredient in Cnidii Monnieri Fructus and etc.
Osthol is a natural coumarin that found in a variety of plants including Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol is an ingredient of a Traditional Chinese Medicine (TCM), and has received attention recently because of its significant and diverse pharmacological activities, including anticancer, anti-osteoporotic, and anti-proliferative activities. (The product is for research purpose only.)
References
- Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells
- Anti-allergic effects of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) and Iits major component, osthol
- Coumarins from Cnidium monnieri and their antiosteoporotic activity
- Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study
- Osthole: a promising lead compound for drug discovery from a Traditional Chinese Medicine (TCM) (a review)
- Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review
PubMed Literature
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