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CAS RN: 147526-32-7 | Product Number: P2071
Pitavastatin Calcium (contains 15% Water at maximum)
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- Calcium (3R,5S,E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate (contains 15% Water at maximum)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
136,00 €
|
1 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | P2071 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__5__0H__4__6CaF__2N__2O__8 = 881.00 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 147526-32-7 |
| Reaxys Registry Number | 7965530 |
| Merck Index (14) | 7508 |
| MDL Number | MFCD01937979 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Chelometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation | +20.0 to +24.0 deg(C=1, CH3CN/H2O) |
| Water | max. 15.0 % |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 23.2° (C=1,CH3CN aq.) |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. |
Related Laws:
| RTECS# | MJ8047045 |
Transport Information:
| HS Number | 2933499090 |
Application
Pitavastatin Calcium: An HMG-CoA Reductase Inhibitor
Pitavastatin calcium (NK-104) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, also known as "a statin". The reductase catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the biosynthetic pathway for cholesterol in the liver. Pitavastatin, an HMG-CoA reductase inhibitor, inhibits cholesterol biosynthesis and reduces plasma triglyceride and total cholesterol levels in animals. (The product is for research purpose only.)
References
- Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs
- Relative Induction of mRNA for HMG CoA Reductase and LDL Receptor by Five Different HMG-CoA Reductase Inhibitors in Cultured Human Cells
- NK-104: a novel synthetic HMG-CoA reductase inhibitor (a review)
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