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Published TCIMAIL newest issue No.198
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CAS RN: 191217-81-9 | Product Number: P2073
Pramipexole Dihydrochloride Monohydrate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Dihydrochloride Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€26.00
|
Contact Us | 20 |
|
| 1G |
€168.00
|
1 | 16 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2073 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__0H__1__7N__3S·2HCl·H__2O = 302.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 191217-81-9 |
| Related CAS RN
|
104632-25-9&104632-26-0 |
| Reaxys Registry Number | 14116907 |
| PubChem Substance ID | 253659970 |
| Merck Index (14) | 7705 |
| MDL Number | MFCD02183927 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -65.0 to -71.0 deg(C=1,MeOH) |
| Water | 5.0 to 7.0 % |
Properties (reference)
| Melting Point | 290 °C(dec.) |
| Specific Rotation | -67° (C=1,MeOH) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | dichloromethane |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| RTECS# | DL3375000 |
Transport Information:
| HS Number | 2934208090 |
Application
A Dopamine D3 Receptor Agonist, Pramipexole
Pramipexole [P2879] and its dihydrochloride are non-ergot dopamine agonists with high relative specificity and full intrinsic activity at the D2 subfamily (D2, D3, D4) of dopamine receptors. The affinity for the D3 receptor subtype is the highest. Specifically, pramipexoles have selective affinity for the D2 subfamily (D2, D3, D4), with a 7-10 fold greater affinity for D3 than for D2 receptor subtypes; affinity for the D4 receptor subtype is 17-fold less than for D3 receptors. In clinical, the dihydrochloride is used for the treatment of Parkinson's disease. Although the precise mechanism of action is unknown, it is believed to be related to its ability to stimulate dopamine receptors in the striatum. (The product is for research purpose only.)
References
- Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors
- Biochemical and pharmacological studies on pramipexole, a potent and selective dopamine D2 receptor agonist
- Mechanisms of action of pramipexole: Effects on receptors
- M. Dziedzicka-Wasylewska, F. Ferrari, R. D. Johnson, J. Mierau, Z. Rogoz, G. Skuza, P. Sokoloff, Rev. Contemp. Pharmacother. 2003, 12, 1.
- Mechanisms of action of pramipexole: putative neuroprotective effects
- J. P. Bennett Jr., P. M. Carvey, T. R. Hinds, R. D. Johnson, W. Le, W. Phillips, V. H. Sethy, F. F. Vincenzi, M. B. H. Youdim, Rev. Contemp. Pharmacother. 2003, 12, 33.
- Pharmacokinetic evaluation of pramipexole
PubMed Literature
Product Articles
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