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CAS RN: 56-54-2 | Product Number: Q0006
Quinidine
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Purity: >85.0%(HPLC)
Synonyms:
- Conquinine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€34.00
|
4 | ≥100 |
|
| 25G |
€167.00
|
2 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Q0006 |
Purity / Analysis Method 
|
>85.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4N__2O__2 = 324.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 56-54-2 |
| Reaxys Registry Number | 3654871 |
| PubChem Substance ID | 87575544 |
| SDBS (AIST Spectral DB) | 2125 |
| Merck Index (14) | 8060 |
| MDL Number | MFCD00135581 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 85.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 169.0 to 174.0 °C |
| Specific rotation [a]20/D | +260 to +275 deg(C=1, EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 172 °C |
| Specific Rotation | 268° (C=1,EtOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 140 mg/l 25 °C |
| Solubility (soluble in) | Benzene, Alcohol, Chloroform |
| Solubility (slightly sol. in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 200-279-0 |
| RTECS# | VA4725000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939200000 |
Application
Quinidine: A Class 1a Antiarrhythmic Agent
Quinidine, a cinchona alkaloid, originally derived from the bark of the Cinchona tree. Quinidine is a class 1a antiarrhythmic agent which interferes both with the sodium (Na+) and potassium (K+) channels, with a pharmacological profile of action similar to that of disopyramide [D2793]. Quinidine inhibits the fast inward sodium current, and depresses the conduction velocity. Consequently, quinidine decreases myocardial excitability. Its sulfate [Q0010] is used clinically. (The product is for research purpose only.)
References
- Quinidine (a review)
- Quinidine revisited (a review)
- Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs (a review)
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