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Published TCIMAIL newest issue No.199
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CAS RN: 6119-47-7 | Product Number: Q0030
Quinine Hydrochloride Dihydrate
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Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€50.00
|
3 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Q0030 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4N__2O__2·HCl·2H__2O = 396.91 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 6119-47-7 |
| Reaxys Registry Number | 8370495 |
| PubChem Substance ID | 87575563 |
| Merck Index (14) | 8061 |
| MDL Number | MFCD00078498 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(Nonaqueous Titration) | 98.0 to 105.0 % |
| Specific rotation [a]20/D | -245 to -255 deg(C=2, 0.1mol/l HCl(calcd.on dried substance) |
| Solubility in hot Water | almost transparency |
| Drying loss | max. 10.0 % |
Properties (reference)
| Melting Point | 160 °C |
| Specific Rotation | -250° (C=2,0.1mol/L HCl) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
Related Laws:
| RTECS# | VA7700000 |
Transport Information:
| HS Number | 2939200000 |
Application
Efflux pump research
Quinine has been reported to inhibit efflux pump in methicillin-resistant Staphylococcus aureus (MRSA).1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Inhibitory and Resistance-Modifying Potential of Plant-Based Alkaloids Against Methicillin-Resistant Staphylococcus aureus (MRSA)
- 1) Fatal Dose of Sulphate of Quinine
- 2) Antimalarial Drug Toxicity (a review)
- 3) Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications (a review)
- 4) Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria (a review)
- 5) Quinine hydrochloride (a review on the physical properties, synthesis, biosynthesis, metabolism and pharmacokinetics, indications and dosages, toxicity and methods of determination)
Application
Quinine: An Antimalarial Substance
Quinine is one of the alkaloids which is included in the bark of cinchona tree and has been researched since 19th century.1) It has an anti-malarial activity2-4) and is considered to inhibit heme polymerase of plasmodium and to indicate toxicity to plasmodium. (The product is for research purpose only)
References
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Documents
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