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CAS RN: 111974-72-2 | Product Number: Q0092
Quetiapine Hemifumarate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
76,00 €
|
1 | 5 |
|
|
| 25G |
264,00 €
|
1 | 8 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | Q0092 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5N__3O__2S·^^1/__2C__4H__4O__4 = 441.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 111974-72-2 |
| Related CAS RN
|
111974-69-7 |
| Reaxys Registry Number | 8378094 |
| PubChem Substance ID | 160871365 |
| Merck Index (14) | 8039 |
| MDL Number | MFCD03423782 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 172.0 to 176.0 °C |
Properties (reference)
| Melting Point | 174 °C |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H370 : Causes damage to organs. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | KK3605000 |
Transport Information:
| HS Number | 2934999090 |
Application
Quetiapine Hemifumarate: A Multi-Acting Receptor Targeted Antipsychotic (MARTA)
Quetiapine hemifumarate is known as a multi-acting receptor targeted antipsychotic (MARTA), such as clozapine [C2547] and olanzapine [O0393]. Quetiapine has greater affinity for serotonin 5-HT2A and dopamine D1 and D2 receptors. Furthemore, quetiapine has various affinities for multiple receptors, including 5-HT1A and α1- and α2-adrenergic receptors. While, quetiapine binds weakly to benzodiazepine (BZD) and muscarinergic M1A receptors. The precise mechanism of action is unknown, but quetiapine is used as a thienobenzodiazepine atypical antipsychotic. (The product is for research purpose only.)
References
- Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence
- Binding of antipsychotic drugs to human brain receptors - focus on newer generation compounds
- Quetiapine in the treatment of schizophrenia and related disorders (a review)
- N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT1A Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity
- Stability-Indicating HPLC Method for the Determination of Quetiapine: Application to Tablets and Human Plasma
- Identification, isolation, synthesis and characterization of impurities of quetiapine fumarate
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