Shipping simulation can be checked by selecting the quantity from 1 to 999 with the - or + button or directly entering then clicking the magnifying glass mark. The number on the left is the quantity that can be shipped according to that schedule.
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Added to Your Shopping Cart
Supplemental Product Information:
Contents (per one capsule)
2,2'-Bipyridyl ca. 0.500 mmol
Uses of Reagent
Applicable to copper-catalyzed reactions due to a ligand encapsulated in HPMC capsules
H301 + H311 : Toxic if swallowed or in contact with skin. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects.
Precautionary Statements
P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
Copper(I) iodide (HPMC encapsulated) (one capsule) and 2,2’-bipyridyl (HPMC encapsulated) (one capsule) were added to a solution of indole (93.7 mg, 800 µmol), 2-bromopyridine (164 mg, 1.04 mmol, 1.3 eq.) and cesium carbonate (521 mg, 1.60 mmol, 2.0 eq.) in DMSO (2.5 mL) at room temperature and the reaction mixture was stirred at 150 °C for 5 hours. After cooling to room temperature, the solution was diluted with ethyl acetate (15 mL) and sat. Na2SO4 aq. (15 mL), and filtered through Celite pad. The filtrate was extracted with ethyl acetate (15 mL x 2) and the organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (ethyl acetate:hexane = 1:10 - 1:5) to afford N-(2-pyridyl)indole (71 mg, 46% yield) as a pale-yellow oil.
Experimenter’s Comments
The reaction mixture was monitored by UPLC. The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose). The capsule has the shape shown in Fig. 1 and 2,2’-bipyridyl (ca. 500 μmol) and copper(I) iodide (ca. 800 μmol) are encapsulated in each capsule, respectively.
Fig. 1. Appearance of the capsule The capsule dissolves in water or polar solvent as shown in Fig. 2. Fig. 2. Capsule disintegrating (left) Immediately after the addition of the capsule, (right) 15 minutes after the addition of the capsule.
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us
for more information.
The lot number searched for is no longer available, and related documentation is no longer provided. Please try a different lot number for this product.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.
The lot number searched for is no longer available, and related documentation is no longer provided. Please try a different lot number for this product.
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.
