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Published TCIMAIL newest issue No.200
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CAS RN: 106516-24-9 | Product Number: S0942
Sertindole
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Purity: >95.0%(HPLC)
Synonyms:
- 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€89.00
|
4 | 38 |
|
|
| 50MG |
€444.00
|
1 | 23 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | S0942 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__6ClFN__4O = 440.95 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 106516-24-9 |
| Reaxys Registry Number | 5364890 |
| PubChem Substance ID | 253660923 |
| Merck Index (14) | 8466 |
| MDL Number | MFCD00867749 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
| Melting Point | 155 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | NJ0621100 |
Transport Information:
| HS Number | 2933399999 |
Application
Sertindole: An Antagonist at Dopamine D2, Serotonin 5-HT2A
Sertindole is an antipsychotic with high affinity for and functions as an antagonist at a number of receptor systems, including dopamine D2 receptors, serotonin 5-HT2A and 5-HT2C receptors, and α1-adrenergic receptors, and low affinity for other receptors. Sertindole undergoes extensive hepatic metabolism by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4 and has an elimination half-life of approximately three days. On the other hand, sertindole can prolong the Q-T interval which is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
References
- Neurochemical and in vivo pharmacological profile of sertindole, a limbic-selective neuroleptic compound
- Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles
- The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG
- Emerging treatments in the management of schizophrenia - focus on sertindole (a review)
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