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Published TCIMAIL newest issue No.198
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CAS RN: 112665-43-7 | Product Number: S0943
Seratrodast
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€57.00
|
1 | 2 |
|
| 1G |
€362.00
|
Contact Us | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0943 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__6O__4 = 354.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 112665-43-7 |
| Reaxys Registry Number | 6489593 |
| PubChem Substance ID | 253662316 |
| Merck Index (14) | 8459 |
| MDL Number | MFCD00875701 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 128 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DA1600050 |
Transport Information:
| HS Number | 2916399090 |
Application
Seratrodast: A Thromboxane-A2 (TXA2) Receptor Antagonist
Seratrodast (AA-2414) is the first thromboxane-A2 (TXA2) receptor antagonist. TXA2, a metabolite of arachidonic acid [A0781], promotes platelet aggregation and vessel constriction, and is released by platelets when these are activated by local tissue damage. Seratrodast, a TXA2 receptor antagonist, reduces bronchial hyperresponsiveness in asthmatic subjects. Seratrodast undergoes cytochrome P450 (CYP) dependent primary metabolism to a major (5-methylhydroxy seratrodast) and a minor (4-hydroxy seratrodast) metabolite. (The product is for research purpose only.)
References
- A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids
- Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414
- Seratrodast (AA-2414) - a novel thromboxane-A2 receptor antagonist (a review)
- Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001)
- Effect of AA-2414, a thromboxane A2 receptor antagonist, on airway inflammation in subjects with asthma
PubMed Literature
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